T cells at work

Development in Motion: Helper T Cells at Work

In mammals, helper T cells orchestrate defense against diverse pathogens. However, these warriors of the immune system can also result in self-inflicted injury culminating in autoimmune and allergic diseases. Recent findings--such as the discovery of the Th17 lineage--have revealed additional complexity in the fates chosen by helper T cells and have begun to reshape our view of how signaling an...

How do Regulatory T Cells Work?

CD4(+) T cells are commonly divided into regulatory T (Treg) cells and conventional T helper (Th) cells. Th cells control adaptive immunity against pathogens and cancer by activating other effector immune cells. Treg cells are defined as CD4(+) T cells in charge of suppressing potentially deleterious activities of Th cells. This review briefly summarizes the current knowledge in the Treg field ...

T Helper Cells Profile and CD4+CD25+Foxp3+Regulatory T Cells in Polycystic Ovary Syndrome

Background: Polycystic ovary syndrome (PCOS) is considered as the most common cause of female infertility that affects 4-10% of women in the reproductive age. Previous studies have shown the role of a balanced immune response in a successful pregnancy and fertility. Objective: To investigate the T helper cells type 1 (Th1) /Th2/Th17/Treg paradigms in peripheral blood of infertile PCOS compared ...

Tumour immunology: T cells work together to fight cancer

A central question in tumour immunology is whether a tumour-specific immune response is capable of controlling tumour progression in cancer patients. Although several animal models have established the role of tumour-specific CD4+ helper and CD8+ cytotoxic T cells in antitumour immunity, a definitive role for these cells in tumour-specific immunity in patients with cancer has yet to be shown. I...

Commentary A New Look at T Cells